Analysis of serum testosterone concentrations from 117 hypogonadal men in the 84-week clinical study of Aveed indicated that serum testosterone concentrations achieved were inversely correlated with the patient's body weight. In 60 patients with pretreatment body weight of ≥ 100 kg, the mean (±SD) serum testosterone average concentration was 426 ± 104 ng/dL. A higher serum testosterone average concentration (568 ± 139 ng/dL) was observed in 57 patients weighing 65 to 100 kg. A similar trend was also observed for maximum serum testosterone concentrations.
Medicines are commonly prescribed for the treatment of sciatica, but evidence for pain medication is poor.  Specifically, low-quality evidence indicates that NSAIDs do not appear to improve immediate pain and all NSAIDs appear about equivalent.    Evidence is also lacking in use of opioids and muscle relaxants by usual means.  In those with sciatica due to piriformis syndrome, botulinum toxin injections may improve pain and or function.  There is little evidence for steroids, either epidural or by pill.   Low-quality evidence supports the use of gabapentin for acute pain relief in those with chronic sciatica.