Non steroid hormones bind to receptors

Because steroids are lipophilic, they diffuse easily through the cell membranes, and therefore have a very large distribution volume. In their target tissues, steroids are concentrated by an uptake mechanism which relies on their binding to intracellular proteins (or " receptors ", see below). High concentration of steroids are also found in adipose tissue, although this is not a target for hormone action. In the human male, adipose tissue contains aromatase activity, and seems to be the main source of androgen-derived estrogens found in the circulation. But most of the peripheral metabolism occurs in the liver and to some extent in the kidneys, which are the major sites of hormone inactivation and elimination, or catabolism (see below).

All bets are off the table when high-dose testosterone and its many metabolites are used illegally, such as with anabolic steroid abuse. Strokes, embolisms, and cardiovascular disease are all more likely, as is sudden death, and liver and kidney disease. 44 In women, acne, irreversible deepening of the voice, baldness, increased facial hair, enlarged sex organs, breast reduction, depression, and infertility have all been reported. In adult men that abuse anabolic steroids, acne, baldness, permanent infertility, gynecomastia, loss of libido, erectile dysfunction, testicle shrinkage, and profuse sweating are all reported side effects. Increased testicular cancer hasn't been reported, though. 45,46

Believe it or not, non-steroid using individuals may experience heart muscle growth through rigorous exercise (such as aerobics). Steroid users differ in that the more they use and the longer they use, the more potential there is for growth. Negative side effects may not surface unless abuse becomes the norm, but it is best not to take the chance. Additionally, consistent steroid users may experience a decrease in the size of the heart muscles when they stop using. This essentially means that the heart starts to shrink. Again, past use/habits are likely to influence the level of change.

David Brownstein, . is a Board-Certified family physician and is one of the foremost practitioners of holistic medicine. He is the Medical Director of the Center for Holistic Medicine in West Bloomfield, Michigan. Dr. Brownstein has lectured internationally to physicians and others about his success in using natural hormones and nutritional therapies in his practice. As an authority and practitioner on the topic, his main goal is to teach the benefits of holistic medicine to the masses and see this advantageous alternative become the sole health solution adopted worldwide.

Non steroid hormones bind to receptors

non steroid hormones bind to receptors

David Brownstein, . is a Board-Certified family physician and is one of the foremost practitioners of holistic medicine. He is the Medical Director of the Center for Holistic Medicine in West Bloomfield, Michigan. Dr. Brownstein has lectured internationally to physicians and others about his success in using natural hormones and nutritional therapies in his practice. As an authority and practitioner on the topic, his main goal is to teach the benefits of holistic medicine to the masses and see this advantageous alternative become the sole health solution adopted worldwide.

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