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When oxycodone (Oxycontin) was compared with placebo, moderate or better pain relief was achieved in 58 percent of patients taking oxycodone versus 18 percent of patients taking placebo. 20 The dosage was titrated from 10 mg twice daily to effect or a maximum of 60 mg twice daily or intolerable side effects. Common side effects included constipation, sedation, and nausea. 20 Another study 21 showed that morphine (MS Contin) and nortriptyline (Pamelor) provided better and equivalent pain relief, respectively, than placebo (decrease in baseline pain by 33 percent). Morphine and nortriptyline had an NNT of 3 and 4, respectively. Side effects for opioids included nausea, constipation, decreased appetite, and sedation. 21

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