Stress and neuroactive steroids

The pharmacological actions of benzodiazepines at the GABA A receptor are similar to those of neurosteroids . Neuroactive steroids are positive allosteric modulators of the GABA A receptor, enhancing GABA function and in turn have effects on mood and other functions. Many benzodiazepines ( diazepam , medazepam , estazolam , temazepam , flunitrazepam and nitrazepam) potently inhibit the enzymes involved in the metabolism of neurosteroids. The tetrahydroxazole ring that cloxazolam and oxazolam have decreases the inhibitory potency of benzodiazepines on neurosteroids. Thus there could be subtle differences between cloxazolam and other benzodiazepines. [12] However, because the parent prodrugs of cloxazolam and oxazolam were tested rather than the active metabolites, this is purely speculative.

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Stress and neuroactive steroids

stress and neuroactive steroids

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