Vzv vasculitis steroids

headache / Early / -
pharyngitis / Delayed / -
nausea / Early / -
abdominal pain / Early / -
sinusitis / Delayed / -
dysmenorrhea / Delayed / -
fatigue / Early / -
rash (unspecified) / Early / -
vomiting / Early / -
arthralgia / Delayed / -
diarrhea / Early / -
dizziness / Early / -
fever / Early / -
rhinorrhea / Early / -
agitation / Early / Incidence not known
photosensitivity / Delayed / Incidence not known
urticaria / Rapid / Incidence not known
alopecia / Delayed / Incidence not known
tremor / Early / Incidence not known
pruritus / Rapid / Incidence not known

Corticosteroids , typically high-dose prednisone (1 mg/kg/day), must be started as soon as the diagnosis is suspected (even before the diagnosis is confirmed by biopsy) to prevent irreversible blindness secondary to ophthalmic artery occlusion. Steroids do not prevent the diagnosis from later being confirmed by biopsy, although certain changes in the histology may be observed towards the end of the first week of treatment and are more difficult to identify after a couple of months. [18] The dose of prednisone is lowered after 2–4 weeks, and slowly tapered over 9–12 months. Tapering may require two or more years. Oral steroids are at least as effective as intravenous steroids, [19] except in the treatment of acute visual loss where intravenous steroids appear to offer significant benefit over oral steroids. [20] It is unclear if adding a small amount of aspirin is beneficial or not as it has not been studied. [21]

Signs and symptoms of the aseptic meningitis syndrome described in association with the use of Orthoclone OKT3 have included: fever, headache, meningismus (stiff neck), and photophobia. Diagnosis is confirmed by cerebrospinal fluid (CSF) analysis demonstrating leukocytosis with pleocytosis, elevated protein and normal or decreased glucose, with negative viral, bacterial, and fungal cultures. The possibility of infection should be evaluated in any immunosuppressed transplant patient with clinical findings suggesting meningitis. Approximately one-third of the patients with a diagnosis of aseptic meningitis had coexisting signs and symptoms of encephalopathy. Most patients with the aseptic meningitis syndrome had a benign course and recovered without any permanent sequelae during therapy or subsequent to its completion or discontinuation. However, because meningitis is a frequent infection encountered in pediatric allograft recipients, and the immunosuppression associated with transplantation increases the risk of opportunistic infection, pediatric patients with signs or symptoms suggestive of meningeal irritation while receiving Orthoclone OKT3 should have lumbar punctures performed to rule out an infectious etiology. (See: PRECAUTIONS: Pediatric Use .)

Vzv vasculitis steroids

vzv vasculitis steroids


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